The research results of the Xiamen University team were published in The journal Nature

2022-04-27 0 By

Xiamen university research team on the journal nature source: author: xiamen daily 2022-02-25: bring the nature website paper screenshot of academician of Chinese Academy of Sciences, xiamen university college of life science professor Lin sc led his team through the “fishing rod” type of chemical probes, “fishing” out of the one hundred play a role of the magic magic pill metformin protein – PEN2.The results of the seven-year study were published yesterday in nature, a leading international academic journal.It has identified the underlying cause of metformin’s life-extending wonders, along the same lines as calorie restriction, and could provide a potential target for screening metformin replacements for diabetes and other metabolic diseases.It is in the research of metformin molecular target that Lin shengcai’s team made the breakthrough.The team, which has long been studying metabolic homeostasis and the mechanisms of metabolic disease, became interested in metformin in 2014.This time, Lin shengcai team first through cooperation with Deng Xianming team of Xiamen University, the latter broke through a number of chemical synthesis problems, synthesis of metformin chemical probe.Lin sc team yesterday, explains the working principle of the probe, like fishing, the front end of the “fishhook” metformin is the molecule, the back end is called a “fishing rod” biotin labeling: the current side met it combined with metformin molecular protein (i.e., target), scientists can through the back end,When metformin is hooked up with its target and analyzed by mass spectrometry, it is possible to know what target metformin binds to.This result can be described as “one sword honed for seven years” — the first author of this paper, Ma Teng, PhD of the 2014 class of Xiamen University, and the co-first authors Tian Xiao and Zhang Baobin have worked for many years to find a real target from more than 2,000 potential targets, and currently there is no means to avoid “false positive” targets.The only way to do that is to sift through them.Using this method, the scientists identified more than 2,000 proteins that might bind to metformin. A series of screening tests led to the discovery of a protein called PEN2 that mediated metformin’s activation of AMPK.When scientists knocked out PEN2, metformin did not activate AMPK, reducing fatty liver disease, alleviating hyperglycemia, and extending life expectancy.These subsequent experiments further demonstrated that PEN2 is the prerequisite for metformin to activate AMPK in the lysosomal pathway.According to Lin’s team, these results strongly suggest that metformin does activate AMPK through PEN2, meaning that PEN2 is metformin’s target.The findings of Lin shengcai’s team deepen people’s understanding of metformin as the “health code” — it is the first time to outline the road map of metformin’s function from the molecular perspective, thus revealing the reason why metformin can lead to longevity, which may be similar to the “seven full” longevity and health strategy.The study also provides a potential target for the screening of metformin substitutes, which currently only targets a few tissues such as the liver and gut. It is hoped that metformin substitutes will be able to target more tissues in the future, leading to better results in the treatment of diabetes and other metabolic diseases.: What is metformin?Metformin, the most commonly used drug to treat type 2 diabetes, was discovered after europeans stumbled upon a species of lily that makes people dizzy because it lowers blood sugar too much. Scientists later extracted and modified the substance to treat diabetes.In recent years, metformin has been found to have a variety of magical effects, in addition to reducing blood sugar, it has the potential to resist diabetes caused by a variety of cancer effects.In healthy people, metformin is also likely to fight aging and prolong life.Therefore, long-term clinical trials have been carried out abroad to explore the influence of metformin on human life expectancy, aiming to find the final evidence of this “health code” for the benefit of future generations.But the molecular target of metformin has been unclear — scientists have no idea where or by which molecules it works, and no way to design strategies to better perform these functions.In other words, humans don’t really understand the nature of metformin’s health code.For context, metformin’s effects are limited. For example, metformin only affects a few tissues, such as the liver and intestines, but not fat tissue.Therefore, if drugs can be designed specifically to target metformin in adipose tissue, it will certainly bring benefits to the treatment of metabolic diseases such as malnutrition, which is increasingly serious.The Lin Shengcai team research results, is considered to have a breakthrough in this area of research.Declaration: The copyright of this article belongs to the original author, if there is a source error or infringement of your legitimate rights and interests, you can contact us through the mailbox, we will promptly deal with.Email address: jpbl@jp.jiupainews.com